The consortium supports three closely connected research projects and
four "cores", the central theme of the work is modeling and visualization
of spatial and temporal patterns of functional activation in the living
human brain as imaged by [15O]water PET and fMRI.
consists of two informatics components - Project 3 (Interactive visualisation
for Neuroimaging) and core D (Neuroinformatics) and two brain/behavioral
components - Project 1 (Temporal Resolution of fMRI) and Project 2
(Reproducible Features of Functional Neuroimages); Cores B and C contain
well-defined research components - 3D brain warping (Core B) and
behavioral correlates of functional neuroimaging data (Core C).
consolidates a earlier collaborative research program under the Human
Brain Project and involves neuroscientists, neuropsychologists, physicists,
mathematicians, statisticians, computer scientists and health informatics
specialists at five U.S. and four institutions outside the U.S.:
The consortium brings together two academic MRI/fMRI centers and three
academic PET centers, hence, provides a unique opportunity to study
the spatial and temporal patterns in functional neuroimages and to compare
and contrast neuroimages acquired during rigorously standardized
neurobehavioral protocols using 1.5T fMRI, 4T fMRI, and [15O]water PET .
- Minneapolis VA Medical Center (USA) University of Minnesota (USA).
- Florida State University (USA).
- Massachusetts General Hospital (Harvard Medical School, USA).
- McLean Hospital (Department of Psychiatry, Harvard Medical School, USA).
- Akita Research Institute of Brain and Blood Vessels (Japan).
- National University Hospital, Rigshospitalet (Denmark).
- Technical University of Denmark.
- Niels Bohr Institute (Denmark).
The main activity for the DTU-group lies in the following projects and cores:
- Project 2
- Reproducible Features of Functional Neuroimages
(S.C. Strother, PI; Lars K. Hansen, Co-PI) has as its principal
goal the identification of reproducible features in PET and fMRI
datasets - within and between participating sites and across imaging
modalities. This project will also assess 1) the impact
of non-linear 3D transformations ("warps") for intersubject registration
and removal of geometric distortion from 4T echo-planar fMRI images and
2) oriental-occidental anatomical and functional differences on the
reproducible features identified using two data analysis strategies - linear
models (e.g., MANOVA, ANCOVA, PCA), and non-linear models (e.g., artificial
neural networks, k-nearest neighbors). In addition, Project 2 investigators
will develop and, in collaboration with Project 3 and the informatics
core (Core D) make available on the WWW benchmark functional activation
datasets, analysis results and associated modeling software. PET and fMRI
datasets will be provided by Project 1 and core B.
- Project 3
- Interactive Visualization for Neuroimaging (D.A.
Rottenberg, PI) will develop an interactive visualization environment
for exploring multidimensional functional data fused with a 3D structural
image volume. This environment will integrate a suite of existing
multidimensional display tools (surface and volume rendering, slice
galleries and projections) with a rich set of navigational tools,
pointers to atlas information and access to the HBP Data Repository
(supported by Core D). Furthermore, Project 3 will develop a VRML
environment that supports the
presentation of modeling and data-analytic results ("case studies")
in an interactive form that is shareable locally and over the Internet.
VRML translations will be initiated from the interactive visualization
environment and will be designed to minimize the need for manual editing
prior to export.
- Core B
- will acquire, archive and ensure quality
control of structural and functional scans at the participating
fMRI and PET centers. In addition, Core B investigators will implement
two non-linear 3D warp algorithms for intersubject registration and
evaluate "intersubject subspace variability" and "model
prediction error" as metrics for optimal warp tuning and